Man and woman riding bicycles portraying TALZENNA® (talazoparib) + XTANDI® (enzalutamide) patients

How Treatment Works

TALZENNA + XTANDI treats HRR gene-mutated mCRPC in 2 different ways.

HRR gene-mutated mCRPC = prostate cancer with certain abnormal inherited or acquired genes called homologous recombination repair (HRR genes) that has spread to other parts of the body (metastatic) and no longer responds to a hormone therapy or surgical treatment to lower testosterone (castration-resistant).


The short answer: TALZENNA may help inhibit cancer cells from repairing themselves, which could lead to even more cell damage that makes it harder for them to survive.

Here is a more in-depth explanation:

The DNA in the nucleus of your cells tells your body how to form and function. DNA is arranged in groupings called genes, which make proteins that drive this process. Importantly, DNA regulates the ability of cells to duplicate to keep the process going. But DNA can become damaged.
Damaged DNA

When there’s damaged DNA, called breaks in the DNA strands, proteins such as PARP,* which exist in your cells, help repair the breaks to keep the cells functioning. This occurs for both normal and cancerous cells.

*PARP = poly (ADP-ribose) polymerase.

PARP proteins helping to repair damaged cells
HRR provides another mechanism for DNA repair. In cells, there may be damage to HRR genes due to mutations. Mutated HRR genes prevent proteins associated with the pathway from being effective in DNA repair.
Mutated HRR gene
TALZENNA is for men whose prostate cancer has an HRR gene mutation. TALZENNA works by inhibiting the repair protein, PARP, from activating the cell's repair pathway. This, in combination with the dysfunction of the mutated HRR gene, makes it harder for cancer cells to survive.
Double strand break

TALZENNA can also affect normal cells, which can lead to side effects.

This is how TALZENNA was shown to work in laboratory studies. Clinical significance is unknown.

How XTANDI Works

XTANDI is an androgen receptor inhibitor.

Here is information about how this treatment works:

Androgens are a group of hormones that include testosterone. Androgen receptor inhibitors decrease how often androgens like testosterone connect with an androgen receptor, and thereby may slow the growth of prostate cancer tumors and cells. Let's take a look inside the cell.

When androgen connects with an androgen receptor, it may cause tumor cells to grow.
Androgen hormone connecting with an androgen receptor

XTANDI helps decrease how often androgen can connect with an androgen receptor. As a result, XTANDI can slow cancer cell growth and the cancer cells may die.

This is how XTANDI was shown to work in laboratory studies. Clinical significance is unknown.

XTANDI® (enzalutamide) inhibits androgen from connecting with an androgen receptor

How to Take TALZENNA

Please talk to your doctor or see XTANDI Patient Information to learn how to take XTANDI.

Talk to Your Doctor About TALZENNA + XTANDI

Our doctor discussion guide can help you ask more focused questions at your next appointment.

Question mark icon

Download Now