What are the possible side effects?
What to keep in mind when starting treatment.
It's important to know what side effects are possible with TALZENNA when taken in combination with XTANDI.
TALZENNA may cause serious side effects, including:
Bone marrow problems called Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML). Some people who have cancer and who have received previous treatment with chemotherapy or certain other medicines for their cancer have developed MDS or AML during or after treatment with TALZENNA. MDS or AML may lead to death. If you develop MDS or AML, your healthcare provider will stop treatment with TALZENNA.
Symptoms of low blood cell counts are common during treatment with TALZENNA, but can be a sign of serious problems, including MDS or AML. Tell your healthcare provider if you have any of the following symptoms during treatment with TALZENNA:
- weakness
- weight loss
- fever
- frequent infections
- blood in urine or stool
- shortness of breath
- feeling very tired
- bruising or bleeding more easily
Your healthcare provider will do blood tests to check your blood cell counts:
- every month during treatment with TALZENNA.
- weekly if you have low blood cell counts that last a long time.
Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with TALZENNA if you get certain side effects.
Common side effects of TALZENNA® (talazoparib) when taken in combination with XTANDI® (enzalutamide)
Some side effects are more expected than others. Your doctor may modify your treatment dose or have other suggestions that could be helpful. Here are some common side effects to be aware of:
- decreased red blood cell counts
- decreased white blood cell counts
- tiredness or weakness
- decreased platelet counts
- decreased calcium in the blood
- nausea
- decreased appetite
- decreased sodium in the blood
- decreased phosphate in the blood
- bone injuries
- decreased magnesium in the blood
- dizziness
- increased bilirubin in the blood
- decreased potassium in the blood
- changes in your sense of taste
TALZENNA may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if this is a concern for you.
These are not all of the possible side effects of TALZENNA. Call your doctor for medical advice about side effects.
You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/MedWatch or call 1-800-FDA-1088.
Talk to your doctor about the potential side effects of XTANDI.
