Couple portraying a TALZENNA® (talazoparib) + XTANDI® (enzalutamide) patient and caregiver in bed reviewing ways to help manage certain side effects

Managing Side Effects

Stay on course with help from your doctor.

Keeping Track of How You Feel on Treatment

Make sure to work with your doctor and care team to monitor side effects you notice, and those you might not. Your healthcare provider may change your dose of TALZENNA or tell you to stop taking TALZENNA depending on how you respond to treatment.

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What you can track

Tell your doctor about any side effects you’re experiencing such as tiredness/weakness, nausea, or decreased appetite.

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What your doctor will track

Some side effects like low red/white blood cell counts, low sodium/calcium in the blood, and low platelet counts can only be seen through blood tests, which your doctor will do:

  • about every month during treatment with TALZENNA
  • every week if you have low blood cell counts that last a long time. Your doctor may stop treatment with TALZENNA until your blood cell counts improve

Tips That May Help With Certain Side Effects

Here are some lifestyle changes that could help you deal with common side effects. These tips come from organizations that focus on supporting patients and have not been studied with TALZENNA. Check with your doctor to see which may be right for you.

Low Red Blood Cell Counts

Treatment may cause a decrease in the number of red blood cells, known as anemia. Anemia may make you feel very tired, short of breath, and/or lightheaded.

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Tip: Ask your doctor if any dietary changes or supplements could be helpful.

Low White Blood Cell Counts

During treatment, you may experience a decrease in white blood cell numbers, which could put you at an increased risk of infection.

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Tip: Remember to wash your hands often and minimize your exposure to people who may be sick.

Tiredness or Weakness

While on treatment, you may experience fatigue. Anemia could also contribute to the feeling of tiredness or weakness.

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Tip: Talk with your doctor about the amount of rest and kinds of activities that are right for you.

Low Platelet Counts

Platelets are cells that help your blood to clot and stop bleeding. Treatment may cause the number of blood-platelet cells to decrease, which could increase your risk of bruising and bleeding.

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Tip: Discuss all over-the-counter medicines you’re taking with your doctor, especially those that may increase your risk of bleeding.

Low Calcium in the Blood

Treatment may cause low levels of calcium in the blood. This may lead to muscle cramps, especially in your back and legs.

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Tip: Talk to your doctor about how you might be able to maintain your calcium levels.


During treatment, you may experience nausea or an upset stomach.

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Tip: It may be helpful to eat several small meals throughout the day instead of 3 large ones. It may help to slowly sip liquids throughout the day.

Decreased Appetite

Treatment may lower your appetite, which could lead to not eating enough nutrients. Nausea may also contribute to loss of appetite.

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Tip: Speak with your care team about foods that might be most nourishing for you.

Low Sodium in the Blood

Treatment may cause sodium levels in the blood to be lower than normal. This may cause nausea and vomiting, low energy, and/or headaches.

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Tip: There may be dietary suggestions your care team can share that could help increase your sodium levels.
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