Why does HRR status matter?
It's key to helping you and your doctor make informed treatment decisions.
HRR gene mutations explained
Homologous recombination repair (HRR) genes are involved in repairing damaged DNA. If you have mutations in HRR genes, not all DNA repair proteins may work properly. This may increase your chances of developing certain types of cancers, including prostate cancer.
Inherited
Passed on from parent to child
Acquired
Can occur randomly and throughout your lifetime
Why HRR status matters
For starters, knowing your HRR status can inform your treatment options, including whether you might be eligible for TALZENNA + XTANDI. But it can also:
- Help you and your doctor decide how to manage your prostate cancer
- Help you find out if your family is at an increased risk of developing certain types of cancers since these mutations may be inherited
How HRR gene mutations are identified
A doctor can perform a genetic and/or biomarker test using a blood, tissue, or saliva sample to check for any inherited or acquired gene mutations.
~1 in 4 men with mCRPC have an HRR gene mutation*
*This is an estimate. The studies and data used to find out how often HRR gene mutations happen in men with advanced prostate cancer varied in their design and patient characteristics. For example, studies can differ in previous or current drug treatment, coexisting conditions, or disease status.
Ask about your HRR status
Our doctor discussion guide can help you get the conversation started.
