A son helping his father, who is a TALZENNA® (talazoparib) + XTANDI® (enzalutamide) patient

Understanding HRR Status

It's key to helping you and your doctor make informed treatment decisions.

HRR Gene Mutations Explained

Homologous recombination repair (HRR) genes are involved in repairing damaged DNA. If you have mutations in HRR genes, not all DNA repair proteins may work properly. This may increase your chances of developing certain types of cancers, including prostate cancer.

There Are 2 Types of HRR Gene Mutations:


Passed on from parent to child


Can occur randomly and throughout your lifetime

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Why HRR Status Matters

For starters, knowing your HRR status can inform your treatment options, including whether you might be eligible for TALZENNA + XTANDI. But it can also:

  • Help you and your doctor decide how to manage your prostate cancer
  • Help you find out if your family is at an increased risk of developing certain types of cancer, since these mutations may be inherited
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How HRR Gene Mutations Are Identified

Your doctor can perform a genetic and/or tumor test to determine if you have HRR gene mutations. Genetic testing can be done using a tissue or blood sample.

~1 in 4 Men With mCRPC Have an HRR Gene Mutation*

Four men representing that about 1 in 4 men with mCRPC have an HRR gene mutation

*This is an estimate because the studies and data used to determine the occurrence of HRR gene mutation in men with advanced prostate cancer varied in their design and patient characteristics, such as different previous or current drug treatment, coexisting conditions, or disease levels.

Four men representing that about 1 in 4 men with mCRPC have an HRR gene mutation

Ask About Your HRR Status

Our doctor discussion guide can help you get the conversation started.

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